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Erectile dysfunction (ED) or impotence and symptoms of benign prostatic hypertrophy (enlarged prostate) are treated by the drug called as Zudena. Zudena is a very unique anti-impotence medication. This drug contains an active component Udenafil, which has been recently approved as PDE-5 inhibitor.
Udenafil commences its effect in response to sexual arousal by stimulating nitric oxide (NO) in the corpus cavernous. The lyase enzyme gets activated by Nitric Oxide (NO) and furtherly increase the levels of cyclic guanosine monophosphate (cGMP). The smooth muscles in blood vessels of the corpus cavernous are relaxed by this cyclic nucleotide, followed by increasing blood flow and producing an erectile.
Zudena induces a long lasting erection. It also has an instant onset action reaching a peak plasma concentration between 1 to 1.5 hours. And it’s half time is 11-13 hours.
Zudena does not promote any protection towards sexually transmitted diseases like HIV or any from pregnancy.
Through interaction with phosphodiesterase type 5 (PDE5) enzyme, erectile function endpoints improve due to Udenafil being a therapeutic agent. Zudena carries a lot of unique properties with a T max of 1.0-1.5 h and a T 1/2 of 11-13 h (a relatively rapid onset and a long duration of action). Therefore, it is recommended and clinically proven that Zudena should be taken once in a day. Udenafil works while using daily and for use as needed. Both the dosing regimens are effective.
Zudena can be consumed on either empty stomach or after eating a meal. The initial recommended dosage of Zudena is 100 mg. Always take this drug 30 minutes before the anticipated sexual activity. Depending on an individual efficacy and tolerability, the dose may be increased to 200 mg after consulting to the doctor. Not more than one dosage in a day is advised. Do not make two halves of Zudena tablet. Swallow it as a whole only.
No need to be on a dosing schedule, if Zudena is taken when needed. The advisable frequency application of Zudena is one time per day.
In case you get overdosed, seek emergency medical help without further delay.
While taking other treatments for erectile dysfunction, stop the use of Zudena.
If you have hypersensitivity with any of the ingredients of Zudena, avoid this drug. Do not go on the medication of Udenafil if you use drugs for chest pain and heart problems including nitrates. These medicines have components like nitro-glycerine, isosorbide dinitrate, and isosorbide mononitrate. In some recreational drugs like amyl nitrate or nitrite (poppers), nitrates are found. Use of nitrate medicines with combination of Zudena can be the cause of sudden or serious decrease in blood pressure.
If on Zudena, then do not operate any machinery or drive.
Always seek advice while using any drug especially Zudena.
If you have any allergic reactions to Udenafil, seek medical help. Allergies such as:
Tell your doctor everything about your past medications and present as well, before going onto the medication of Zudena. Some medicines are as follows:
Inhibitors of cytochrome P450 isozyme CYP3A4 such as ritonavir, ketoconazole, indinavir, cimetidine, erythromycin, Iitraconazole, grapefruit juice may improvise the effect of Zudena.
Ketoconazole (400 mg) increases the Cmax and bioavailability of Zudena (100 mg) around 2-fold (212%) and 0.8-fold (85%), respectively.
The effect of Zudena also increases by ritonavir and indinavir substantially.
Dexamethasone, anticonvulsants drugs and rifampin (carbamazepine, phenytoin and phenobarbital) may give a kick start to the metabolism of Zudena, so combine application with the above given medicines weakens the effect of Udenafil.
The combine application of Udenafil (30 mg / kg orally) and nitro-glycerine (2.5 mg / kg once, w / w) does not cause any effect on the pharmacokinetics of Udenafil, but the side by side use of nitro-glycerine and of Udenafil is not advisable due to possible drop in blood pressure.
Zudena and drugs from the category of alpha-blockers are vasodilator, therefore, in the combine admission should be taken at the minimal dosage.
If you thought that you’ve been overdosed on Zudena, see your doctor right away.
The temperature to store Zudena should not be higher than 86° F (30° C). Keep it in a dry and dark place. Never keep this in the bathroom. Remember to keep this away from pets and children.
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